Abstract
Background: Psoriasis, a common and chronic inflammatory skin disease, can reduce the life quality of the patients. To date, many advances have been provided for the management of psoriasis. For example, it has shown that proinflammatory cytokines play major roles in the pathogenesis of disease. Although various biologic medications targeting the different pathological mechanisms have been developed and studied for the management of the disease, scientific studies are still performed in order to treat the disease completely.
The Remember/Regeneration Therapy Method (RTM) is a novel holistic medicine aproach that targets physiopathological differences in quadruplet body structures, and includes various complementary methods such as acupuncture, ozone theapy and phytotherapy especially in different rates which vary depending on certain diseases.
Case Presentation: We present four plaque psoriasis cases (three severe and one moderate plaque psoriasis) successfully healed with the RTM therapy without a significant side effects in a short time such as four months. In all patients, psychological stress was determined as the triggering factor.
Conclusion: RTM may provide consistent results for psoriasis and similar many diseases by using different RTM combinations which include different holistic methods and its’ different doses, treatment duration and sessions. Identification of epigenetically regulated genes related to psoriasis may be promising in order to develop epigenetic drugs for disease management. For that purpose, further scientific studies which contain aforementioned features are needed.

Key words: Psoriasis, RTM method, holistic medicine