E-ISSN 2534-9821
 

Original Research 


Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles

Hartono Gunardi, Turyadi Turyadi, Susan Irawati Ie, David Handojo Muljono.

Abstract
Background. Some healthy individuals do not response to hepatitis B vaccination. The precise mechanism for non-responsiveness is unknown yet, although it has been associated with human leukocyte antigen (HLA), a host factor. This study investigated the association between HLA-DRB1 alleles and hepatitis B vaccine response in adolescents.
Methods. Senior high-school and college students aged 15-20 years old who had received primary hepatitis B vaccination during 0-5 year-old with non-protective anti-HBs were recruited via stratified random sampling for Hepatitis B marker screening and booster administration. Anti-HBs was tested one month afterwards. All non-responders and randomly selected high responders were typed for HLA-DRB1. Non-responders were given additional booster doses and anti-HBs was evaluated one month afterwards.
Results. There were 213 students who had completed primary hepatitis B vaccination at 0-5 year age screened for Hepatitis B markers. Among these, 89 were negative for HBsAg, anti-HBc and anti-HBs, thus eligible for enrollment. However only 84 gave their consent and participated in this study. Among 84 subjects, three did not respond to one dose of hepatitis B booster vaccine and were categorized as non-responders. The HLA-DRB1 alleles identified in non-responders were HLA-DRB1*0403, DRB1*1219, and DRB1*1301. Non-responsiveness to hepatitis B vaccine was not permanent, all non-responders seroconverted after administration of two or three doses of booster vaccine.
Discussion. This study confirmed the association between certain HLA-DR alleles and lack of antibody response to hepatitis B vaccine.
Conclusions. The presence of certain HLA-DRB1 alleles in non-responders demonstrated that HLA pattern influenced the immune response to hepatitis B vaccination. Administration of additional booster doses to non-responders could elicit protective immunity.

Key words: hepatitis B, vaccination, booster, adolescent, HLA, non-responsiveness


 
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How to Cite this Article
Pubmed Style

Gunardi H, Turyadi T, Ie SI, Muljono DH, . Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles. doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents


Web Style

Gunardi H, Turyadi T, Ie SI, Muljono DH, . Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles. http://www.mdpub.net/?mno=123217 [Access: March 09, 2021]. doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents


AMA (American Medical Association) Style

Gunardi H, Turyadi T, Ie SI, Muljono DH, . Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles. doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents



Vancouver/ICMJE Style

Gunardi H, Turyadi T, Ie SI, Muljono DH, . Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles. doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents



Harvard Style

Gunardi, H., Turyadi, T., Ie, S. I., Muljono, D. H. & (2021) Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles. doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents



Turabian Style

Gunardi, Hartono, Turyadi Turyadi, Susan Irawati Ie, David Handojo Muljono, and . 2021. Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles. doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents



Chicago Style

Gunardi, Hartono, Turyadi Turyadi, Susan Irawati Ie, David Handojo Muljono, and . "Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles." doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents



MLA (The Modern Language Association) Style

Gunardi, Hartono, Turyadi Turyadi, Susan Irawati Ie, David Handojo Muljono, and . "Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles." doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents



APA (American Psychological Association) Style

Gunardi, H., Turyadi, T., Ie, S. I., Muljono, D. H. & (2021) Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles. doi:10.5455/IJMRCR.Non-Responsiveness-To-Hepatitis-B-Vaccination-Adolescents