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Review Article
Online Published: 02 Dec 2018
 


Do immune cytokines (TFN-á) have a role in neuropathic pain?

Muhammad Raheel Minhas, Tahir Iqbal.


Abstract
Immune system consists of specialized cells known as immune cells that release mediators termed as cytokines. Immune system is activated in response to tissue injury or disease and initiates the process of inflammation that results in the development of inflammatory pain. Similarly, injury secondary to disease or lesion to the somatosensory system can activate immune system that causes functional and structural changes in the somatosensory system that results in the development of neuropathic pain. The International Association for Study of Pain (IASP) therefore defines neuropathic pain as “pain caused by a lesion or disease of the somatosensory system”. Emerging evidence suggest that immune cytokines play a pivotal role in the pathogenesis of neuropathic pain in animal models of NP. Human trials confirming such findings are increasing in number, however, failure of therapeutic trials targeting specific cytokines raised controversy. Animal research confirms the role of immune cytokines in the pathogenesis of neuropathic pain.

Key words: cytokines, TNF, neuropathic pain


 
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How to Cite this Article
Pubmed Style

Minhas MR, Iqbal T. Do immune cytokines (TFN-á) have a role in neuropathic pain?. Int J Med Rev Case Rep. 2019; 3(1): 38-41. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines

Web Style

Minhas MR, Iqbal T. Do immune cytokines (TFN-á) have a role in neuropathic pain?. https://www.mdpub.net/?mno=9882 [Access: April 02, 2025]. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines

AMA (American Medical Association) Style

Minhas MR, Iqbal T. Do immune cytokines (TFN-á) have a role in neuropathic pain?. Int J Med Rev Case Rep. 2019; 3(1): 38-41. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines


Vancouver/ICMJE Style

Minhas MR, Iqbal T. Do immune cytokines (TFN-á) have a role in neuropathic pain?. Int J Med Rev Case Rep. (2019), [cited April 02, 2025]; 3(1): 38-41. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines


Harvard Style

Minhas, M. R. & Iqbal, . T. (2019) Do immune cytokines (TFN-á) have a role in neuropathic pain?. Int J Med Rev Case Rep, 3 (1), 38-41. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines


Turabian Style

Minhas, Muhammad Raheel, and Tahir Iqbal. 2019. Do immune cytokines (TFN-á) have a role in neuropathic pain?. International Journal of Medical Reviews and Case Reports, 3 (1), 38-41. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines


Chicago Style

Minhas, Muhammad Raheel, and Tahir Iqbal. "Do immune cytokines (TFN-á) have a role in neuropathic pain?." International Journal of Medical Reviews and Case Reports 3 (2019), 38-41. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines


MLA (The Modern Language Association) Style

Minhas, Muhammad Raheel, and Tahir Iqbal. "Do immune cytokines (TFN-á) have a role in neuropathic pain?." International Journal of Medical Reviews and Case Reports 3.1 (2019), 38-41. Print. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines


APA (American Psychological Association) Style

Minhas, M. R. & Iqbal, . T. (2019) Do immune cytokines (TFN-á) have a role in neuropathic pain?. International Journal of Medical Reviews and Case Reports, 3 (1), 38-41. doi:10.5455/IJMRCR.neuropathic-pain-immune-cytokines


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