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Online Publishing Date:
24 / 07 / 2022

 


The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis

Sari Wulan Dwi Sutanegara, U Tei Dominica Fredlina.


Abstract
Background: Dewandaru plant (Eugenia uniflora L.) is a plant that contains flavonoids with anti-inflammatory, anti-allergy and antioxidant effects that have various clinically proven benefits.
Aims: To determine the effectiveness of Dewandaru (Eugenia uniflora L.) leaf crude extract on total IgE levels in Wistar rats with ovalbumin-induced allergic rhinitis.
Methods: This is a true experimental study with a randomized post-test-only control group design. This study used 28 male Wistar rats randomly divided into 4 groups (n=7 in each group), i.e. negative control group (without therapy), 100 mg/kg BW in extract group, 200 mg/kg BW in extract group, and positive control group (mometasone furoate). Rats were sensitized with ovalbumin intraperitoneally for 14 days, followed by intranasal ovalbumin exposure on the 15th day for 14 days with intervention. Nasal symptom scores and IgE serum levels were assessed in all groups.
Results: There were significant differences in nasal symptoms scores between groups. Nasal symptom scores were significantly lower in the positive control group and treatment group than in the negative control group (p<0.001), and there was no significant difference between the positive control group and the treatment group (p=0.362 and p=0.457). However, there was no significant difference in mean IgE levels (p=0.705).
Conclusion: Dewandaru leaf crude extract is not effective in reducing total IgE levels but is effective in reducing symptoms of allergic rhinitis and has similar effects to topical corticosteroids.

Key words: Allergic rhinitis, rat, flavonoid


 
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Pubmed Style

Sutanegara SWD, Fredlina UTD. The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis. Int J Med Rev Case Rep. 2022; 6(11): 49-53. doi:10.5455/IJMRCR.172-1622118116

Web Style

Sutanegara SWD, Fredlina UTD. The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis. https://www.mdpub.net/?mno=84204 [Access: April 05, 2024]. doi:10.5455/IJMRCR.172-1622118116

AMA (American Medical Association) Style

Sutanegara SWD, Fredlina UTD. The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis. Int J Med Rev Case Rep. 2022; 6(11): 49-53. doi:10.5455/IJMRCR.172-1622118116


Vancouver/ICMJE Style

Sutanegara SWD, Fredlina UTD. The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis. Int J Med Rev Case Rep. (2022), [cited April 05, 2024]; 6(11): 49-53. doi:10.5455/IJMRCR.172-1622118116


Harvard Style

Sutanegara, S. W. D. & Fredlina, . U. T. D. (2022) The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis. Int J Med Rev Case Rep, 6 (11), 49-53. doi:10.5455/IJMRCR.172-1622118116


Turabian Style

Sutanegara, Sari Wulan Dwi, and U Tei Dominica Fredlina. 2022. The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis. International Journal of Medical Reviews and Case Reports, 6 (11), 49-53. doi:10.5455/IJMRCR.172-1622118116


Chicago Style

Sutanegara, Sari Wulan Dwi, and U Tei Dominica Fredlina. "The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis." International Journal of Medical Reviews and Case Reports 6 (2022), 49-53. doi:10.5455/IJMRCR.172-1622118116


MLA (The Modern Language Association) Style

Sutanegara, Sari Wulan Dwi, and U Tei Dominica Fredlina. "The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis." International Journal of Medical Reviews and Case Reports 6.11 (2022), 49-53. Print. doi:10.5455/IJMRCR.172-1622118116


APA (American Psychological Association) Style

Sutanegara, S. W. D. & Fredlina, . U. T. D. (2022) The effectiveness of Dewandaru (Eugenia uniflora l.) Leaf crude extract on immunoglobulin E level in Wistar rats with allergic rhinitis. International Journal of Medical Reviews and Case Reports, 6 (11), 49-53. doi:10.5455/IJMRCR.172-1622118116


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