Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum

Vishnu Asokan; Dinesan M; Bindu G; Ajayakumar T

doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

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Original Research

Online Publishing Date:
28 / 01 / 2022

Int J Med Rev Case Rep. 2022; 6(1): 77-82

doi: 10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum

Vishnu Asokan, Dinesan M, Bindu G, Ajayakumar T.

Abstract
Aim:
Colorectal cancer is the second most common cancer in women and third among men worldwide. The aim of the study is to assess radiological downstaging, pathological response, toxicity following short-course radiation therapy in the neoadjuvant treatment of locally advanced carcinoma rectum.
Materials & methods:
20 Patients with locally advanced carcinoma rectum were studied by a prospective single-group Cohort Study. Target volumes were delineated using RTOG contouring guidelines. Short course radiotherapy with a dose of 25 Gy in 5 fractions, once daily for 5 days delivered using 3D conformal radiotherapy. The toxicity was assessed following radiation and during surgery. After 6 weeks, pelvic MRI did and categorized according to MRI tumour regression grade. Surgery was done at 6-8 weeks. Pathological response assessed using Mandard tumour regression grade.
Results:
66.67 % of patients with T3N1 disease and 88.89 patients with T3N2 disease had statistically significant grade 3 tumour regression on MRI. 66.67% of patients with T3N2 disease and 50% with T3N1 disease attained statistically non-significant grade 3 pathological tumour regression. One T3N0 patient attained pathologic complete response. Most of the patients had grade1 or grade 2 toxicity.
Findings:
Tumour downstaging occurs when surgery is delayed by 6-8 weeks after short-course radiotherapy in T3N0 /N+ locally advanced rectal cancers, with an acceptable toxicity profile

Key words: Chemoradiation, Short course Radiotherapy, Tumour Regression Grade

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Pubmed Style

Asokan V, M D, G B, T A. Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum. Int J Med Rev Case Rep. 2022; 6(1): 77-82. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

Web Style

Asokan V, M D, G B, T A. Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum. https://www.mdpub.net/?mno=77777 [Access: April 04, 2024]. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

AMA (American Medical Association) Style

Asokan V, M D, G B, T A. Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum. Int J Med Rev Case Rep. 2022; 6(1): 77-82. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

Vancouver/ICMJE Style

Asokan V, M D, G B, T A. Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum. Int J Med Rev Case Rep. (2022), [cited April 04, 2024]; 6(1): 77-82. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

Harvard Style

Asokan, V., M, . D., G, . B. & T, . A. (2022) Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum. Int J Med Rev Case Rep, 6 (1), 77-82. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

Turabian Style

Asokan, Vishnu, Dinesan M, Bindu G, and Ajayakumar T. 2022. Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum. International Journal of Medical Reviews and Case Reports, 6 (1), 77-82. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

Chicago Style

Asokan, Vishnu, Dinesan M, Bindu G, and Ajayakumar T. "Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum." International Journal of Medical Reviews and Case Reports 6 (2022), 77-82. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

MLA (The Modern Language Association) Style

Asokan, Vishnu, Dinesan M, Bindu G, and Ajayakumar T. "Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum." International Journal of Medical Reviews and Case Reports 6.1 (2022), 77-82. Print. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

APA (American Psychological Association) Style

Asokan, V., M, . D., G, . B. & T, . A. (2022) Tumour response and toxicity analysis of preoperative short-course radiation therapy followed by delayed surgery in carcinoma rectum. International Journal of Medical Reviews and Case Reports, 6 (1), 77-82. doi:10.5455/IJMRCR.TUMOURRESPONSEANDTOXICITYANALYSISOFPREOPERATIVESHORT-COURSERADIATION

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