E-ISSN 2534-9821
 

Review Article 


Transdermal Patches: A review of a new drug delivery system approach

Ade Abiyyatun Mahdiyyah, Nuzul Wahyuning Diyah, Esti Hendradi.

Abstract
Background: Transdermal patch is a transdermal delivery system that can overcome problems in conventional drug administration, such as oral drug administration. Patches can provide controlled drug release and have advantages over oral administration, such as avoiding first-pass metabolism, increasing drug bioavailability, avoiding adverse effects on the gastrointestinal (GI) tract, minimizing patient variability, maintaining a constant drug in plasma, and providing a stable therapeutic effect. The effectiveness of a patch is determined by the drug's ability to release from the patch matrix and penetrate the stratum corneum. The methods used to make the patches are divided into single layer, multi-layer, reservoir system, and matrix system patches. The basic components of a patch are polymer matrix, membrane, drug, permeation enhancer, pressure-sensitive adhesives, backing film, release liner, and plasticizer.
Methods of review: This review refers to several previously published data regarding physical characteristics and transdermal drug release. This review also explains the patch as a transdermal drug delivery system.
Conclusion: This review focuses on patch analysis methods after the manufacturing process, such as physical characteristics test, in vitro drug release test, in vitro skin permeation test, skin irritation test, and stability test, as well as some explanations related to transdermal drug delivery system.

Key words: Patch, transdermal, characteristics, in vitro release, in vitro skin permeation


 
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How to Cite this Article
Pubmed Style

Mahdiyyah AA, Diyah NW, Hendradi E. Transdermal Patches: A review of a new drug delivery system approach. Int J Med Rev Case Rep. 2022; 6(9): 25-31. doi:10.5455/IJMRCR.172-1641124566


Web Style

Mahdiyyah AA, Diyah NW, Hendradi E. Transdermal Patches: A review of a new drug delivery system approach. https://www.mdpub.net/?mno=140224 [Access: December 15, 2023]. doi:10.5455/IJMRCR.172-1641124566


AMA (American Medical Association) Style

Mahdiyyah AA, Diyah NW, Hendradi E. Transdermal Patches: A review of a new drug delivery system approach. Int J Med Rev Case Rep. 2022; 6(9): 25-31. doi:10.5455/IJMRCR.172-1641124566



Vancouver/ICMJE Style

Mahdiyyah AA, Diyah NW, Hendradi E. Transdermal Patches: A review of a new drug delivery system approach. Int J Med Rev Case Rep. (2022), [cited December 15, 2023]; 6(9): 25-31. doi:10.5455/IJMRCR.172-1641124566



Harvard Style

Mahdiyyah, A. A., Diyah, . N. W. & Hendradi, . E. (2022) Transdermal Patches: A review of a new drug delivery system approach. Int J Med Rev Case Rep, 6 (9), 25-31. doi:10.5455/IJMRCR.172-1641124566



Turabian Style

Mahdiyyah, Ade Abiyyatun, Nuzul Wahyuning Diyah, and Esti Hendradi. 2022. Transdermal Patches: A review of a new drug delivery system approach. International Journal of Medical Reviews and Case Reports, 6 (9), 25-31. doi:10.5455/IJMRCR.172-1641124566



Chicago Style

Mahdiyyah, Ade Abiyyatun, Nuzul Wahyuning Diyah, and Esti Hendradi. "Transdermal Patches: A review of a new drug delivery system approach." International Journal of Medical Reviews and Case Reports 6 (2022), 25-31. doi:10.5455/IJMRCR.172-1641124566



MLA (The Modern Language Association) Style

Mahdiyyah, Ade Abiyyatun, Nuzul Wahyuning Diyah, and Esti Hendradi. "Transdermal Patches: A review of a new drug delivery system approach." International Journal of Medical Reviews and Case Reports 6.9 (2022), 25-31. Print. doi:10.5455/IJMRCR.172-1641124566



APA (American Psychological Association) Style

Mahdiyyah, A. A., Diyah, . N. W. & Hendradi, . E. (2022) Transdermal Patches: A review of a new drug delivery system approach. International Journal of Medical Reviews and Case Reports, 6 (9), 25-31. doi:10.5455/IJMRCR.172-1641124566