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Online Publishing Date:
05 / 02 / 2023

 


Vitamin D Deficiency: A Potential Factor Behind Depression

Archana Nimesh, Aparna Das, Thoraya Mohamed Elhassan A-Elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali AlShaikh, Sathishbabu Murugaiyan.


Abstract
Depression, a leading cause of disability affecting around 264 million people globally has multifactorial causes like psychosocial, biological, genetic and hormonal. Vitamin D, a neuroactive steroid easily crosses blood brain barrier and has widespread receptors in the brain tissue suggesting that vitamin D could have a role in the brain functioning. This paper reviews if vitamin D deficiency is associated with depression and the possible biochemical mechanisms for explaining the same. For this review, scientific studies published till December 2021 were searched on PubMed, Google Scholar and Google using keywords, vitamin D, vitamin D deficiency, depression, mechanisms, association and supplementation. Studies have found that vitamin D is important for expression of neurotransmitters, neuroimmunomodulation and antioxidant production. Neurotrophic hypothesis and monoamine neurotransmission hypothesis explains the biochemical mechanisms behind depression. Many studies found insufficient vitamin D levels being associated with depression and the symptoms improved upon vitamin D supplementation. Thus, it is recommended that serum vitamin D in depression patients should be monitored and normalized if found deficient. Vitamin D supplementation as an adjuvant therapy to standard antidepressants therapy could be more effective to treat depression not responding to standalone vitamin D supplementation. Vitamin D may be used to treat depression especially in patients with poor compliance to antidepressant drugs.

Key words: vitamin D, vitamin D deficiency, depression, mechanism, association, vitamin D supplementation


 
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How to Cite this Article
Pubmed Style

Nimesh A, Das A, A-Elgadir TME, Bharti RK, Monir R, AlShaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep. 2022; 6(21): 25-30. doi:10.5455/IJMRCR.172-1649779386

Web Style

Nimesh A, Das A, A-Elgadir TME, Bharti RK, Monir R, AlShaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. https://www.mdpub.net/?mno=13956 [Access: April 05, 2024]. doi:10.5455/IJMRCR.172-1649779386

AMA (American Medical Association) Style

Nimesh A, Das A, A-Elgadir TME, Bharti RK, Monir R, AlShaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep. 2022; 6(21): 25-30. doi:10.5455/IJMRCR.172-1649779386


Vancouver/ICMJE Style

Nimesh A, Das A, A-Elgadir TME, Bharti RK, Monir R, AlShaikh AA, Murugaiyan S. Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep. (2022), [cited April 05, 2024]; 6(21): 25-30. doi:10.5455/IJMRCR.172-1649779386


Harvard Style

Nimesh, A., Das, . A., A-Elgadir, . T. M. E., Bharti, . R. K., Monir, . R., AlShaikh, . A. A. & Murugaiyan, . S. (2022) Vitamin D Deficiency: A Potential Factor Behind Depression. Int J Med Rev Case Rep, 6 (21), 25-30. doi:10.5455/IJMRCR.172-1649779386


Turabian Style

Nimesh, Archana, Aparna Das, Thoraya Mohamed Elhassan A-Elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali AlShaikh, and Sathishbabu Murugaiyan. 2022. Vitamin D Deficiency: A Potential Factor Behind Depression. International Journal of Medical Reviews and Case Reports, 6 (21), 25-30. doi:10.5455/IJMRCR.172-1649779386


Chicago Style

Nimesh, Archana, Aparna Das, Thoraya Mohamed Elhassan A-Elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali AlShaikh, and Sathishbabu Murugaiyan. "Vitamin D Deficiency: A Potential Factor Behind Depression." International Journal of Medical Reviews and Case Reports 6 (2022), 25-30. doi:10.5455/IJMRCR.172-1649779386


MLA (The Modern Language Association) Style

Nimesh, Archana, Aparna Das, Thoraya Mohamed Elhassan A-Elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali AlShaikh, and Sathishbabu Murugaiyan. "Vitamin D Deficiency: A Potential Factor Behind Depression." International Journal of Medical Reviews and Case Reports 6.21 (2022), 25-30. Print. doi:10.5455/IJMRCR.172-1649779386


APA (American Psychological Association) Style

Nimesh, A., Das, . A., A-Elgadir, . T. M. E., Bharti, . R. K., Monir, . R., AlShaikh, . A. A. & Murugaiyan, . S. (2022) Vitamin D Deficiency: A Potential Factor Behind Depression. International Journal of Medical Reviews and Case Reports, 6 (21), 25-30. doi:10.5455/IJMRCR.172-1649779386


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