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19 / 10 / 2020

 


Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience

Luiz Fernando Fonseca, Karina Soares Loutfi, Clara Gontijo Camelo, José Humberto Santos Soares, Paula Carvalho Ribeiro, Raquel Machado Tófani, Bárbara Campos Mattos.


Abstract
Introduction: The treatment of refractory epilepsy in childhood is a challenge in medical practice. The authors describe the experience with cannabidiol (CBD) use in patients with refractory epilepsy. Objectives: To evaluate the response to CBD treatment in the control of epileptic seizures, as well as their tolerability and side effects. Methods: A retrospective descriptive, series of cases study was performed, with data collected from 24 patients aged 1 to 45 years, diagnosed with refractory epilepsy, and who used CBD as adjunctive therapy. The CBD dose used ranged from 2.5mg/kg/day to 14mg/kg/day, with an average of 6.3mg/kg/day. Results: Of the twenty four patients analyzed, there was a reduction in seizure frequency in 19 patients (79.2%), and of these, five patients (20.8%) presented seizure reduction between 50-79% (moderate response), ten patients (41.6%) presented seizure reduction between 80-99% (marked response) and four patients (16.6%) presented complete seizure resolution. On the other hand, five patients (20.8%) did not respond to CBD treatment. Of these, one patient had no change in seizure pattern and four patients (16.6%) had increased seizure frequency. Among the positive aspects of the use of CBD were reduction in the number of hospitalizations, reduction in polytherapy (70% of cases) and improvement in some cognitive and behavioral aspects. The adverse effects mentioned were considered mild. Conclusion: CBD represents a promising alternative in refractory patients to conventional anticonvulsants

Key words: Anticonvulsants, Cannabidiol, Cannabis sativa, Epilepsy, Pharmacological Treatment


 
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How to Cite this Article
Pubmed Style

Fonseca LF, Loutfi KS, Camelo CG, Soares JHS, Ribeiro PC, Tófani RM, Mattos BC. Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience. Int J Med Rev Case Rep. 2020; 4(11): 53-58. doi:10.5455/IJMRCR.Artisanal-cannabidiol

Web Style

Fonseca LF, Loutfi KS, Camelo CG, Soares JHS, Ribeiro PC, Tófani RM, Mattos BC. Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience. https://www.mdpub.net/?mno=114639 [Access: April 04, 2024]. doi:10.5455/IJMRCR.Artisanal-cannabidiol

AMA (American Medical Association) Style

Fonseca LF, Loutfi KS, Camelo CG, Soares JHS, Ribeiro PC, Tófani RM, Mattos BC. Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience. Int J Med Rev Case Rep. 2020; 4(11): 53-58. doi:10.5455/IJMRCR.Artisanal-cannabidiol


Vancouver/ICMJE Style

Fonseca LF, Loutfi KS, Camelo CG, Soares JHS, Ribeiro PC, Tófani RM, Mattos BC. Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience. Int J Med Rev Case Rep. (2020), [cited April 04, 2024]; 4(11): 53-58. doi:10.5455/IJMRCR.Artisanal-cannabidiol


Harvard Style

Fonseca, L. F., Loutfi, . K. S., Camelo, . C. G., Soares, . J. H. S., Ribeiro, . P. C., Tófani, . R. M. & Mattos, . B. C. (2020) Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience. Int J Med Rev Case Rep, 4 (11), 53-58. doi:10.5455/IJMRCR.Artisanal-cannabidiol


Turabian Style

Fonseca, Luiz Fernando, Karina Soares Loutfi, Clara Gontijo Camelo, José Humberto Santos Soares, Paula Carvalho Ribeiro, Raquel Machado Tófani, and Bárbara Campos Mattos. 2020. Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience. International Journal of Medical Reviews and Case Reports, 4 (11), 53-58. doi:10.5455/IJMRCR.Artisanal-cannabidiol


Chicago Style

Fonseca, Luiz Fernando, Karina Soares Loutfi, Clara Gontijo Camelo, José Humberto Santos Soares, Paula Carvalho Ribeiro, Raquel Machado Tófani, and Bárbara Campos Mattos. "Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience." International Journal of Medical Reviews and Case Reports 4 (2020), 53-58. doi:10.5455/IJMRCR.Artisanal-cannabidiol


MLA (The Modern Language Association) Style

Fonseca, Luiz Fernando, Karina Soares Loutfi, Clara Gontijo Camelo, José Humberto Santos Soares, Paula Carvalho Ribeiro, Raquel Machado Tófani, and Bárbara Campos Mattos. "Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience." International Journal of Medical Reviews and Case Reports 4.11 (2020), 53-58. Print. doi:10.5455/IJMRCR.Artisanal-cannabidiol


APA (American Psychological Association) Style

Fonseca, L. F., Loutfi, . K. S., Camelo, . C. G., Soares, . J. H. S., Ribeiro, . P. C., Tófani, . R. M. & Mattos, . B. C. (2020) Artisanal cannabidiol as adjunct treatment for refractory epilepsy: A Brazilian experience. International Journal of Medical Reviews and Case Reports, 4 (11), 53-58. doi:10.5455/IJMRCR.Artisanal-cannabidiol


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