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Online Publishing Date:
04 / 02 / 2020

 


Neutrophil to lymphocyte ratio in immunotherapy for malignancies

Bassim Kobrossy.


Abstract
In the quest for a simple and effective biomarker for PD-1 antibody efficacy many candidates have emerged. The simplest one is the ratio between neutrophils and lymphocytes (NLR) in peripheral blood. Since 2012 the emergence of checkpoint inhibitor therapy has introduced a new paradigm in cancer therapy, adding a powerful tool in the oncology treatment armamentarium. The progress achieved in clinical trials have revealed efficacy in different tumor types and with different immunotherapy combinations. However optimal duration of therapy, optimal dose, optimal schedule, are for the most part unknown. In this review we will discuss the utility of information obtained from the peripheral blood CBC as a contributor to solving this question.
 

Key words: pd1, checkpoint inhibitors, neutrophil to lymphocyte ratio


 
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Pubmed Style

Bassim Kobrossy. Neutrophil to lymphocyte ratio in immunotherapy for malignancies. Int J Med Rev Case Rep. 2020; 4(1): 11-13. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology

Web Style

Bassim Kobrossy. Neutrophil to lymphocyte ratio in immunotherapy for malignancies. https://www.mdpub.net/?mno=82035 [Access: April 04, 2024]. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology

AMA (American Medical Association) Style

Bassim Kobrossy. Neutrophil to lymphocyte ratio in immunotherapy for malignancies. Int J Med Rev Case Rep. 2020; 4(1): 11-13. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology


Vancouver/ICMJE Style

Bassim Kobrossy. Neutrophil to lymphocyte ratio in immunotherapy for malignancies. Int J Med Rev Case Rep. (2020), [cited April 04, 2024]; 4(1): 11-13. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology


Harvard Style

Bassim Kobrossy (2020) Neutrophil to lymphocyte ratio in immunotherapy for malignancies. Int J Med Rev Case Rep, 4 (1), 11-13. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology


Turabian Style

Bassim Kobrossy. 2020. Neutrophil to lymphocyte ratio in immunotherapy for malignancies. International Journal of Medical Reviews and Case Reports, 4 (1), 11-13. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology


Chicago Style

Bassim Kobrossy. "Neutrophil to lymphocyte ratio in immunotherapy for malignancies." International Journal of Medical Reviews and Case Reports 4 (2020), 11-13. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology


MLA (The Modern Language Association) Style

Bassim Kobrossy. "Neutrophil to lymphocyte ratio in immunotherapy for malignancies." International Journal of Medical Reviews and Case Reports 4.1 (2020), 11-13. Print. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology


APA (American Psychological Association) Style

Bassim Kobrossy (2020) Neutrophil to lymphocyte ratio in immunotherapy for malignancies. International Journal of Medical Reviews and Case Reports, 4 (1), 11-13. doi:10.5455/IJMRCR.Neutrophil-Lyphocyte-Ratio-oncology


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