E-ISSN 2534-9821
 

Review Article 


Chemical Toxic Strategies to Target Various Types of Cancer Cell

Wenhan Cheng.

Abstract
Chemical toxicology is a rapidly evolving field that targets various types of cancer cells. The strategies are based on “glucose metabolism”, “mechanisms of cell death”, “bioactivation” and “enzyme induction”. Cancer cells heavily rely on abnormal glycolysis, which involves overexpressed hexokinase II (HKII). This catalyzes the first step of glycolysis, therefore, therapeutically targeting HKII. This allows it to change critical metabolic pathway in cancer cells. Abnormal glycolysis coverts large amount ATP to promote growth, so, another attractive target for tumor therapy is apoptosis induced by glucose deprivation. Cancer cells not only consume glucose, but also require glutamine, another major nutrient. Specifically, glutamine which is precursor of intermediates of Krebs cycle. As a result, glutamine starvation may also be a future strategy that researchers could use for cancer therapy.
Even though glucose metabolism is one of the major cancer therapy targets in chemical toxicology, some reactive metabolite byproduct of glycolysis has become a hot topic for treating cancers, such as methylglyoxal will reacts with glutathione (GSH) in non-enzymatical condition to form lactoylglutathione (LGSH). This could accumulate to a high concentration level of tumor cells and promote tumor growth. This allows the argument to be made that methylglyoxal inhibits the detoxification of reactive metabolites is, as it suppresses the growth of cancer cell.

Key words: glucose metabolism, mechanisms of cell death, bioactivation, enzyme induction, Warburg effect


 
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Pubmed Style

Wenhan Cheng. Chemical Toxic Strategies to Target Various Types of Cancer Cell. Int J Med Rev Case Rep. 2020; 4(5): 151-155. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies


Web Style

Wenhan Cheng. Chemical Toxic Strategies to Target Various Types of Cancer Cell. http://www.mdpub.net/?mno=107068 [Access: September 23, 2020]. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies


AMA (American Medical Association) Style

Wenhan Cheng. Chemical Toxic Strategies to Target Various Types of Cancer Cell. Int J Med Rev Case Rep. 2020; 4(5): 151-155. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies



Vancouver/ICMJE Style

Wenhan Cheng. Chemical Toxic Strategies to Target Various Types of Cancer Cell. Int J Med Rev Case Rep. (2020), [cited September 23, 2020]; 4(5): 151-155. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies



Harvard Style

Wenhan Cheng (2020) Chemical Toxic Strategies to Target Various Types of Cancer Cell. Int J Med Rev Case Rep, 4 (5), 151-155. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies



Turabian Style

Wenhan Cheng. 2020. Chemical Toxic Strategies to Target Various Types of Cancer Cell. International Journal of Medical Reviews and Case Reports, 4 (5), 151-155. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies



Chicago Style

Wenhan Cheng. "Chemical Toxic Strategies to Target Various Types of Cancer Cell." International Journal of Medical Reviews and Case Reports 4 (2020), 151-155. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies



MLA (The Modern Language Association) Style

Wenhan Cheng. "Chemical Toxic Strategies to Target Various Types of Cancer Cell." International Journal of Medical Reviews and Case Reports 4.5 (2020), 151-155. Print. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies



APA (American Psychological Association) Style

Wenhan Cheng (2020) Chemical Toxic Strategies to Target Various Types of Cancer Cell. International Journal of Medical Reviews and Case Reports, 4 (5), 151-155. doi:10.5455/IJMRCR.Chemical-Toxic-Strategies