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Original Research

Online Publishing Date:
03 / 10 / 2021

 


A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.

Utkarsh Kumar, Sanjeev Kumar Gupta, Anjali Singh, S.K. Singh, Shreekant Bharti.


Abstract
The aim of this study is to see the effects of glycaemic control on Immunohistochemical markers (Ki67, CD34 and Neurofilament protein) in diabetic neuropathic ulcers. It is an observational study with 30 patients regards to patient’s demographic data, clinical, pathological and wound characteristics and their correlation with tissue Ki67, NFP, CD34 expression after glycaemic control. Inclusion criteria of Diabetic foot ulcers present for > 6 weeks having peripheral neuropathy. In our study, the Mean wound area before Glycemic control was32.43±24.72cm2 & after glycemic control was reduced to 13.00±9.68 cm2 with complete healing of ulcers in two patients after 6 weeks. The majority of patients (46.7%) were between 6-10% LI(Labelling index) of Ki67 on day1 and there seems to be an increase in Ki-67 with an increase in tissue proliferation, as the majority of patients (46.7%) were in between 16-20% LI(Labelling index) of Ki67 after 6 weeks(P=0.025). None of our patients (n=30) showed immunostaining for neurofilament protein at presentation, However, after glycemic control, 2/30(6.66%) patients show NFP expression. The difference was not statistically significant. Expression of CD34 was significantly increased after Glycemic control (p=0.005). So, we conclude that Glycemic control decreases the wound surface area and thereby help in the healing of foot ulcers. Glycemic control results in increased expression of CD34 and Ki67 but there is no significant change in Neurofilament Protein.

Key words: glycaemic control, Immunohistochemical marker, Peripheral neuropathy, Diabetic control


 
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How to Cite this Article
Pubmed Style

Kumar U, Gupta SK, Singh A, Singh S, Bharti S. A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.. Int J Med Rev Case Rep. 2021; 5(8): 88-95. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control

Web Style

Kumar U, Gupta SK, Singh A, Singh S, Bharti S. A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.. https://www.mdpub.net/?mno=34418 [Access: April 05, 2024]. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control

AMA (American Medical Association) Style

Kumar U, Gupta SK, Singh A, Singh S, Bharti S. A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.. Int J Med Rev Case Rep. 2021; 5(8): 88-95. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control


Vancouver/ICMJE Style

Kumar U, Gupta SK, Singh A, Singh S, Bharti S. A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.. Int J Med Rev Case Rep. (2021), [cited April 05, 2024]; 5(8): 88-95. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control


Harvard Style

Kumar, U., Gupta, . S. K., Singh, . A., Singh, . S. & Bharti, . S. (2021) A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.. Int J Med Rev Case Rep, 5 (8), 88-95. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control


Turabian Style

Kumar, Utkarsh, Sanjeev Kumar Gupta, Anjali Singh, S.K. Singh, and Shreekant Bharti. 2021. A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.. International Journal of Medical Reviews and Case Reports, 5 (8), 88-95. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control


Chicago Style

Kumar, Utkarsh, Sanjeev Kumar Gupta, Anjali Singh, S.K. Singh, and Shreekant Bharti. "A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.." International Journal of Medical Reviews and Case Reports 5 (2021), 88-95. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control


MLA (The Modern Language Association) Style

Kumar, Utkarsh, Sanjeev Kumar Gupta, Anjali Singh, S.K. Singh, and Shreekant Bharti. "A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.." International Journal of Medical Reviews and Case Reports 5.8 (2021), 88-95. Print. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control


APA (American Psychological Association) Style

Kumar, U., Gupta, . S. K., Singh, . A., Singh, . S. & Bharti, . S. (2021) A Study of Changes in Immunohistochemical Markers (Ki67, CD34, neurofilament protein) Peripheral Neuropathic Diabetic Foot Ulcers after Glycaemic Control.. International Journal of Medical Reviews and Case Reports, 5 (8), 88-95. doi:10.5455/IJMRCR.diabetic-foot-ulcer-glicemic-control


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