E-ISSN 2534-9821
 
2023, Vol: 7, Issue: 6
7 / 6Current Issue Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles
Required files to be uploaded

Copyright Transfer Form

Original Research

Online Publishing Date:
16 / 12 / 2020

 


The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy

Ramon Satya Pradhana, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, Jimmy Eko Budi Hartono.


Abstract
Background: Breast cancer is the most common malignancy in women. Chemotherapy is the main modality for treating breast cancer which affect the cognitive function. Chemotherapy increases the levels of cytokines, damage genetic material, or damage the brain’s grey matter causing cognitive deficits and neurotoxicity.
Objective: To determine the incidence of cognitive impairment before the first injection and after the third injection with an interval of 3 weeks in breast cancer patients receiving chemotherapy and hormonal therapy.
Methods: This was an analytical observational study with a prospective cohort design of postoperative breast cancer patients receiving chemotherapy who met the inclusion and exclusion criteria. Cognitive function tests were carried out using the Moca-Ina questionnaire. Data analysis included descriptive statistics, Mann Whitney test, and Spearman's bivariate correlation test. The results were significant if the p value <0.05.
Results: A total of 40 breast cancer patients were included in this study. Cognitive impairment increased after the third injection of chemotherapy in the injection chemotherapy group compared to the hormonal therapy group. There was a significant difference between pre-chemotherapy and post-third injection of breast cancer patients who received chemotherapy compared to patients who received hormonal therapy (p=0.005). There was a correlation between cognitive impairment scores and neuropathic pain before (p=0.175; rho= -0.219) and after the third chemotherapy (p=0.017; rho= -0.377).
Conclusion: Cognitive impairment increased after the third injection of chemotherapy. There was a significant difference between pre-post the third chemotherapy. There was also a correlation between cognitive impairment scores and neuropathic pain of breast cancer patients who received chemotherapy.

Key words: Chemotherapy, Cognitive Function Impairment, Neuropathic Pain


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Ramon Satya Pradhana
Articles by Hexanto Muhartomo
Articles by M. I. Widiastuti
Articles by Aris Catur Bintoro
Articles by Endang Kustiowati
Articles by Jimmy Eko Budi Hartono
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep. 2020; 4(11): 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer

Web Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. https://www.mdpub.net/?mno=20589 [Access: April 04, 2024]. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer

AMA (American Medical Association) Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep. 2020; 4(11): 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Vancouver/ICMJE Style

Pradhana RS, Muhartomo H, Widiastuti MI, Bintoro AC, Kustiowati E, Hartono JEB. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep. (2020), [cited April 04, 2024]; 4(11): 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Harvard Style

Pradhana, R. S., Muhartomo, . H., Widiastuti, . M. I., Bintoro, . A. C., Kustiowati, . E. & Hartono, . J. E. B. (2020) The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. Int J Med Rev Case Rep, 4 (11), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Turabian Style

Pradhana, Ramon Satya, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, and Jimmy Eko Budi Hartono. 2020. The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. International Journal of Medical Reviews and Case Reports, 4 (11), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Chicago Style

Pradhana, Ramon Satya, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, and Jimmy Eko Budi Hartono. "The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy." International Journal of Medical Reviews and Case Reports 4 (2020), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


MLA (The Modern Language Association) Style

Pradhana, Ramon Satya, Hexanto Muhartomo, M. I. Widiastuti, Aris Catur Bintoro, Endang Kustiowati, and Jimmy Eko Budi Hartono. "The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy." International Journal of Medical Reviews and Case Reports 4.11 (2020), 122-126. Print. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


APA (American Psychological Association) Style

Pradhana, R. S., Muhartomo, . H., Widiastuti, . M. I., Bintoro, . A. C., Kustiowati, . E. & Hartono, . J. E. B. (2020) The Comparison of Cognitive Function Impairment in Breast Cancer Patients Receiving Injection and Hormonal Chemotherapy. International Journal of Medical Reviews and Case Reports, 4 (11), 122-126. doi:10.5455/IJMRCR.Cognitive-Function-Impairment-Breast-Cancer


Author LoginReviewer LoginAbout PublisherEditorial PoliciesEditorial Review PolicyPeer Review PolicyEditorial & Peer Review ProcessAuthor's Rights and ObligationsPublication Ethics and Publication Malpractice StatementConflict of Interest PolicyPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesDigital Archiving & Preservation PoliciesStatement of Informed ConsentAdvertising PolicyTerms of UseLicense InformationCopyright Information

About International Journal of Medical Reviews and Case Reports

International Journal of Medical Reviews and Case Reports  (Int J Med Rev Case Rep)ISSN: 2534-9821The International Journal of Medical Reviews and Ca ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Any correspondence, queries or additional requests for information on the manuscript submission process should be sent to the International Journal of Medical Reviews and Case Reports editorial office as follows:

Bulgarian Association of Young Surgeons (BAYS);

National Center of Public Health and Analyses (NCPHA), floor 2, office № 31,  Sofia 1431, Bulgaria.

inkov@journalmedica.com

Financial department is managed by International Sci Ink Press. 

It is a company registered in Bulgaria with registered no. 205414288 and registered address at 57 Antim I str., Vazrazhdane, Sofia, 1303, Bulgaria.

Tel: +359883427500