E-ISSN 2534-9821
 

Case Report 


Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency

Muneer Hassan Albagshi, Jaber A Alhabeeb, Randa Adel Hussein, Hakeema Alkamis, Murtadha Albagshi.

Abstract
Glucose 6 phosphate dehydrogenase deficiency (G6PD deficiency) is the commonest red blood cell enzyme disorder that affects hundreds of millions around the globe. The red cells deficient in the enzyme become vulnerable to oxidative stress after exposure to certain drugs, chemicals, or food leading to hemolysis. We present a five-year-old boy admitted to burn unit after scold burn by boiling water. He was treated with an application of silver sulfadiazine cream to the burn sites, paracetamol, and intravenous fluids. The boy developed pallor and jaundice on the fifth day of admission with evidence of acute hemolysis and documented G6PD deficiency during the incidence. We hypothesize that sliver sulfadiazine could be absorbed through burn and trigger hemolysis in G6PD deficient individuals; therefore, replacing this antibiotic with a safe one is advised in these individuals, as well as introducing neonatal screening for G6PD deficiency in the high prevalent communities to avoid oxidative triggers and increase awareness in both health care workers as well as the general population.

Key words: Acute hemolysis, G6PD deficiency, Burn


 
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How to Cite this Article
Pubmed Style

Albagshi MH, Alhabeeb JA, Hussein RA, Alkamis H, Albagshi M. Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency. Int J Med Rev Case Rep. 2021; 5(10): 58-60. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild


Web Style

Albagshi MH, Alhabeeb JA, Hussein RA, Alkamis H, Albagshi M. Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency. https://www.mdpub.net/?mno=120162 [Access: December 16, 2023]. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild


AMA (American Medical Association) Style

Albagshi MH, Alhabeeb JA, Hussein RA, Alkamis H, Albagshi M. Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency. Int J Med Rev Case Rep. 2021; 5(10): 58-60. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild



Vancouver/ICMJE Style

Albagshi MH, Alhabeeb JA, Hussein RA, Alkamis H, Albagshi M. Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency. Int J Med Rev Case Rep. (2021), [cited December 16, 2023]; 5(10): 58-60. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild



Harvard Style

Albagshi, M. H., Alhabeeb, . J. A., Hussein, . R. A., Alkamis, . H. & Albagshi, . M. (2021) Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency. Int J Med Rev Case Rep, 5 (10), 58-60. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild



Turabian Style

Albagshi, Muneer Hassan, Jaber A Alhabeeb, Randa Adel Hussein, Hakeema Alkamis, and Murtadha Albagshi. 2021. Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency. International Journal of Medical Reviews and Case Reports, 5 (10), 58-60. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild



Chicago Style

Albagshi, Muneer Hassan, Jaber A Alhabeeb, Randa Adel Hussein, Hakeema Alkamis, and Murtadha Albagshi. "Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency." International Journal of Medical Reviews and Case Reports 5 (2021), 58-60. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild



MLA (The Modern Language Association) Style

Albagshi, Muneer Hassan, Jaber A Alhabeeb, Randa Adel Hussein, Hakeema Alkamis, and Murtadha Albagshi. "Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency." International Journal of Medical Reviews and Case Reports 5.10 (2021), 58-60. Print. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild



APA (American Psychological Association) Style

Albagshi, M. H., Alhabeeb, . J. A., Hussein, . R. A., Alkamis, . H. & Albagshi, . M. (2021) Topical Silver Sulfadiazine Trigger Hemolysis in a Child with Burn and Glucose 6 Phosphate Dehydrogenase Deficiency. International Journal of Medical Reviews and Case Reports, 5 (10), 58-60. doi:10.5455/IJMRCR.TopicalSilverSulfadiazineTriggerHemolysisinaChild